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Clinically Supported Results of Natural ED Treatments

This article reviews human evidence on antioxidant supplementation and dietary antioxidant patterns in erectile dysfunction (ED). It summarizes meta analyses, population studies, and genetic causal work. It also lists limits and practical guidance.

Meta analysis evidence

  • Ramasamy et al., 2025: pooled 23 double blind randomized placebo controlled trials with 1,583 men. Antioxidant supplementation improved IIEF EF by about 5.5 points vs placebo over a median 12 weeks (95% CI 3.7 to 7.3; p < 0.001). Journal page: World Journal of Men’s Health.
  • Greater benefit was seen in men with more severe baseline ED. Source: WJMH.
  • Adverse events were uncommon and mild. No serious events reported in pooled trials. Source: PubMed. Open access PDF: PMC.

Population and dietary studies

  • Higher Composite Dietary Antioxidant Index scores were linked with lower ED prevalence in NHANES men after adjustment. Open access article: J Health Popul Nutr 2024. PubMed record: PubMed.
  • Additional analyses report negative associations between antioxidant intake patterns and ED severity. See Scientific Reports 2024 and related NHANES work on oxidative balance score: Scientific Reports 2024.

Mendelian randomization findings

  • Chen et al., 2025: bidirectional MR suggests higher vitamin A (retinol) levels may increase ED risk. Other antioxidants showed mixed or weaker signals. PubMed record: PubMed. PDF: WJMH PDF.

Which antioxidants show signals

  • L arginine appears in several positive trials and in blends within the meta analysis dataset. Effects vary by dose and combination. Source: WJMH.
  • Pycnogenol commonly features in blends that achieved clinically meaningful IIEF EF gains vs placebo. Source: WJMH.
  • Vitamin E, carotenoids, selenium show supportive associations in observational work and appear in some blends, while single nutrient RCT evidence is less consistent. Source: WJMH.

Safety and limitations

  • Heterogeneity is very high across trials due to differences in baseline severity, agents, doses, and durations. This limits precision of pooled estimates. Source: PubMed.
  • Most trials lasted 4 to 24 weeks. Long term efficacy and safety are uncertain. Source: PubMed.
  • Genetic evidence cautions against excessive fat soluble vitamins. More is not always better, particularly for vitamin A. Source: WJMH.
  • Observational associations can reflect residual confounding despite adjustment. Sources: JHPN, Scientific Reports.

Practical implications for Erectimus users

  • Antioxidant supplementation improved erectile function by about 5 to 6 IIEF EF points over roughly 8 to 12 weeks in pooled RCTs. Expect incremental change, not instant effects. Source: PubMed.
  • Choose quality formulations with clear dosing and ingredient transparency. Blends often performed better than single agents in trials.
  • Use alongside lifestyle measures that support vascular health: diet rich in antioxidant foods, regular exercise, weight management, and smoking cessation.
  • Consult a clinician if you have chronic disease or take prescription medicines, especially where fat soluble vitamins are involved.

Where to learn more on this site

References

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